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Original Article

Vol. 2 No. 2 (2023): May 2023

Relationship between hypercholesterolemia and sleep quality among older adults

DOI
https://doi.org/10.55048/jpns71
Submitted
September 3, 2022
Published
2023-05-30

Abstract

Background: Hypercholesterolemia refers to the buildup of fat in the blood, leading to the accumulation of fatty deposits on the walls of blood vessels, known as atherosclerosis. High cholesterol levels can adversely affect health, including the sleep quality of the older adults, leading to physical and psychological health issues.

Objective: This study aims to examine the relationship between hypercholesterolemia and sleep quality among older adults.

Methods: A cross-sectional design was utilized in this study, with a sample size of 60 respondents selected through purposive sampling. Data collection involved the use of a cholesterol level observation sheet and the Pittsburgh Sleep Quality Index (PSQI) questionnaire. Data analysis was conducted using the Spearman Rank correlation. 

Results: The results revealed a significant relationship between hypercholesterolemia and sleep quality in the older adults (p < 0.0001; r = 0.802). This indicates a positive correlation between hypercholesterolemia and sleep quality among the older adults.

Conclusions: The study concludes that as hypercholesterolemia levels become more normalized, sleep quality improves. Conversely, higher levels of hypercholesterolemia are associated with poorer sleep quality in the older adults.

References

  1. Arifin, H., Chou, K. R., Ibrahim, K., Fitri, S. U. R., Pradipta, R. O., Rias, Y. A., Sitorus, N., Wiratama, B. S., Setiawan, A., Setyowati, S., Kuswanto, H., Mediarti, D., Rosnani, R., Sulistini, R., & Pahria, T. (2022). Analysis of modifiable, non-modifiable, and physiological risk factors of non-communicable diseases in indonesia: Evidence from the 2018 Indonesian Basic Health Research. J Multidiscip Healthc, 15, 2203-2221. https://doi.org/10.2147/jmdh.S382191
  2. Barikani, A., Javadi, M., & Rafiei, S. (2019). Sleep quality and blood lipid composition among patients with diabetes. Int J Endocrinol Metab, 17(3), e81062. https://doi.org/10.5812/ijem.81062
  3. Bista, B., Dhimal, M., Bhattarai, S., Neupane, T., Xu, Y. Y., Pandey, A. R., Townsend, N., Gyanwali, P., & Jha, A. K. (2021). Prevalence of non-communicable diseases risk factors and their determinants: Results from STEPS survey 2019, Nepal. PLOS ONE, 16(7), e0253605. https://doi.org/10.1371/journal.pone.0253605
  4. Chen, Z., Zhang, X., Duan, Y., Mo, T., Liu, W., Ma, Y., & Yin, P. (2022). The relationship between sleep duration and blood lipids among chinese middle-aged and older adults: Cross-lagged path analysis from CHARLS. Front Public Health, 10, 868059. https://doi.org/10.3389/fpubh.2022.868059
  5. Dai, X., Hummel, S. L., Salazar, J. B., Taffet, G. E., Zieman, S., & Schwartz, J. B. (2015). Cardiovascular physiology in the older adults. J Geriatr Cardiol, 12(3), 196-201. https://doi.org/10.11909/j.issn.1671-5411.2015.03.015
  6. Gangwisch, J. E., Malaspina, D., Babiss, L. A., Opler, M. G., Posner, K., Shen, S., Turner, J. B., Zammit, G. K., & Ginsberg, H. N. (2010). Short sleep duration as a risk factor for hypercholesterolemia: analyses of the National Longitudinal Study of Adolescent Health. Sleep, 33(7), 956-961. https://doi.org/10.1093/sleep/33.7.956
  7. Grandner, M. A., Seixas, A., Shetty, S., & Shenoy, S. (2016). Sleep duration and diabetes risk: population trends and potential mechanisms. Curr Diab Rep, 16(11), 106. https://doi.org/10.1007/s11892-016-0805-8
  8. Hansson, G. K., & Libby, P. (2006). The immune response in atherosclerosis: a double-edged sword. Nature reviews immunology, 6(7), 508-519.
  9. Kotani, K., Adachi, S., Tsuzaki, K., Sakane, N., & Gugliucci, A. (2010). The association between resistin, high-density lipoprotein cholesterol and carotid atherosclerosis in elderly women with hypertension. International Journal of Cardiology, 141(2), 193-194. https://doi.org/https://doi.org/10.1016/j.ijcard.2008.11.066
  10. Liu, X., Lang, L., Wang, R., Chen, W., Ren, X., Lin, Y., Chen, G., Pan, C., Zhao, W., Li, T., Han, C., He, L., & Gu, Y. (2021). Poor sleep quality and its related risk factors among university students. Ann Palliat Med, 10(4), 4479-4485. https://doi.org/10.21037/apm-21-472
  11. Maryati, H. (2017). The correlation of cholesterol levels with blood pressure hypertension patients in Sidomulyo Rejoagung Village Distric. Jurnal Keperawatan, 8(2), 127-137.
  12. MB, S. K., & Ganz, P. (1997). Role of endothelial dysfunction in coronary artery disease and implications for therapy. The American Journal of Cardiology, 80(9), 11I-16I.
  13. Miner, B., & Kryger, M. H. (2017). Sleep in the Aging Population. Sleep Med Clin, 12(1), 31-38. https://doi.org/10.1016/j.jsmc.2016.10.008
  14. Montecino-Rodriguez, E., Berent-Maoz, B., & Dorshkind, K. (2013). Causes, consequences, and reversal of immune system aging. J Clin Invest, 123(3), 958-965. https://doi.org/10.1172/jci64096
  15. Nursalam. (2017). Metodologi Penelitian Ilmu Keperawatan (4th Ed). Salemba Medika.
  16. Ou, S. M., Chen, Y. T., Shih, C. J., & Tarng, D. C. (2017). Impact of physical activity on the association between lipid profiles and mortality among older people. Sci Rep, 7(1), 8399. https://doi.org/10.1038/s41598-017-07857-7
  17. Palatini, P., Virdis, A., Masi, S., Mengozzi, A., Casiglia, E., Tikhonoff, V., Cicero, A. F. G., Ungar, A., Parati, G., Rivasi, G., Salvetti, M., Barbagallo, C. M., Bombelli, M., Dell’Oro, R., Bruno, B., Lippa, L., D’Elia, L., Masulli, M., Verdecchia, P., . . . Borghi, C. (2023). Hyperuricemia increases the risk of cardiovascular mortality associated with very high HdL-cholesterol level. Nutrition, Metabolism and Cardiovascular Diseases, 33(2), 323-330. https://doi.org/https://doi.org/10.1016/j.numecd.2022.11.024
  18. Pu Lin, M. D., Kai-Ting, C., Yan-An, L., Tzeng, I. S., Hai-Hua, C., & Jau-Yuan, C. (2017). Association between self-reported sleep duration and serum lipid profile in a middle-aged and elderly population in Taiwan: a community-based, cross-sectional study. BMJ OPEN, 7(10), e015964. https://doi.org/10.1136/bmjopen-2017-015964
  19. Riskesdas. (2018). Riset Kesehatan Dasar 2018. Kementrian Kesehatan Republik Indonesia, 1-100. https://doi.org/1 Desember 2013
  20. Sharifi-Rad, J., Rodrigues, C. F., Sharopov, F., Docea, A. O., Can Karaca, A., Sharifi-Rad, M., Kahveci Kar?ncaoglu, D., Gülseren, G., ?enol, E., Demircan, E., Taheri, Y., Suleria, H. A. R., Özçelik, B., Nur Kasapo?lu, K., Gültekin-Özgüven, M., Da?kaya-Dikmen, C., Cho, W. C., Martins, N., & Calina, D. (2020). Diet, lifestyle and cardiovascular diseases: Linking pathophysiology to cardioprotective effects of natural bioactive compounds. Int J Environ Res Public Health, 17(7). https://doi.org/10.3390/ijerph17072326
  21. Shochat, T. (2012). Impact of lifestyle and technology developments on sleep. Nat Sci Sleep, 4, 19-31. https://doi.org/10.2147/nss.S18891
  22. Suzuki, K., Miyamoto, M., & Hirata, K. (2017). Sleep disorders in the elderly: Diagnosis and management. J Gen Fam Med, 18(2), 61-71. https://doi.org/10.1002/jgf2.27
  23. Xing, C., Huang, X., Zhang, Y., Zhang, C., Wang, W., Wu, L., Ding, M., Zhang, M., & Song, L. (2020). Sleep disturbance induces increased cholesterol level by NR1D1 Mediated CYP7A1 Inhibition. Front Genet, 11, 610496. https://doi.org/10.3389/fgene.2020.610496
  24. Zaki, N., Alashwal, H., & Ibrahim, S. (2020). Association of hypertension, diabetes, stroke, cancer, kidney disease, and high-cholesterol with COVID-19 disease severity and fatality: A systematic review. Diabetes & Metabolic Syndrome: Clinical Research & Reviews, 14(5), 1133-1142. https://doi.org/https://doi.org/10.1016/j.dsx.2020.07.005

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