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Original Article

Vol. 1 No. 3 (2022): September 2022

The effect of drinking cold water on nausea and vomiting among patient with post-chemotherapy breast cancer

March 7, 2022


Background: Nausea, vomiting after chemotherapy is still major problem that interferes with the process of treating cancer, especially breast cancer. There are 2 things that can be done to reduce nausea, vomiting, pharmacologically and non-pharmacologically. Drinking cold water is one of the non-pharmacological ways for patients who experience nausea, vomiting after chemotherapy. These actions can reduce acute nausea and vomiting delayed due to chemotherapy 

Purpose: The purpose of this study was to determine the effect of drinking cold water on nausea and vomiting after chemotherapy in breast cancer patients in RSUP M. Djamil Padang.

Methods: This research was a time series. Sampling by consecutive sampling and determination of intervention and control groups by randomization of simple subject allocations. The research sample consisted of 38 respondents, consisting of 19 respondents as an intervention group who were treated with cold drinking water for 3 days and 19 respondents as a control group 

Results: Testing the difference in the decrease in the average score of nausea and vomiting in the intervention group using the repeated measure ANOVA test. The results showed an average decrease in the intervention group of < 0.001.

Conclusions: The conclusion significantly drinking cold water can reduce nausea and vomiting after chemotherapy in breast cancer patients in RSUP M. Djamil Padang. It is recommended that drinking cold water be applied as part of nursing intervention in providing nursing care to patients who experience nausea and vomiting after chemotherapy.


  1. Aapro, M. (2015). Pathophysiology of Nausea and Vomiting. Springer Healthcare.
  2. Adams, J. (2014). Using abdominal massage in bowel management. Nurs Stand, 28(45), 37–42. DOI:
  3. American Cancer Society. (2018a). About Breast Cancer. American Cancer Society.
  4. American Cancer Society. (2018b). Cancer Facts & Figures 2018. American Cancer Society.
  5. American Cancer Society. (2018c). Non-drug Treatments for Nausea and Vomiting Self-hypnosis Systematic desensitization Acupuncture or acupressure. American Cancer Society.
  6. Babic, T., & Browning, K. N. (2014). The role of vagal neurocircuits in the regulation of nausea and vomiting. European journal of pharmacology, 722, 38–47. DOI:
  7. Backes, T. P., & Fitzgerald, K. (2016). Fluid consumption, exercise, and cognitive performance. Biology of Sport, 33(3), 291–296 DOI:
  8. Bayo, J., Fonseca, P. J., Hernando, S., Servitja, S., Calvo, A., Falagan, S., García, E., González, I., De Miguel, M. J., Pérez, Q., Milena, A., Ruiz, A., & Barnadas, A. (2012). Chemotherapy-induced nausea and vomiting: Pathophysiology and therapeutic principles. Clinical and Translational Oncology, 14(6), 413–422. DOI:
  9. Cho, H. M., & Yoo, B. (2015). Rheological characteristics of cold thickened beverages containing xanthan gum-based food thickeners used for dysphagia diets. Journal of the Academy of Nutrition and Dietetics, 115(1),106-111. DOI:
  10. Clark Snow, R., Afronti, M. Lou, & Rittenverg, C. N. (2018). Chemotherapy- induced nausea and vomiting (CINV) and adherence to antiemetic guidelines: results of a survey of oncology nurses. Support Care Cancer, 26, 557–564. 10.1007/s00520-017-3866-6 DOI:
  11. Dahlan, M. S. (2017). Statistik Untuk Kedokteran dan Kesehatan (6th ed.). Epidemiologi Indonesia.
  12. Eccles, R., Du-plessis, L., Dommels, Y., & Wilkinson, J. E. (2013). Cold pleasure. Why we like ice drinks , ice-lollies and ice cream. Appetite, 71, 357–360. DOI:
  13. Gordon, P., Legrand, S. B., & Walsh, D. (2014). Nausea and vomiting in advanced cancer. European Journal of Pharmacology, 722, 187-191. DOI:
  14. Greene, F., Page, D., Fleming, I., & Fritz, A. (2017). Breast. In AJCC Cancer Staging Manual. DOI:
  15. Greenlee, H., DuPont-Reyes, M. J., Balneaves, L. G., Carlson, L. E., Cohen, M. R., Deng, G., Johnson, J. A., Mumber, M., Seely, D., Zick, S. M., Boyce, L. M., & Tripathy, D. (2017). Clinical practice guidelines on the evidence-based use of integrative therapies during and after breast cancer treatment. CA: A Cancer Journal for Clinicians, 67(3), 194-232. DOI:
  16. Hosseini, M., Tirgari, B., Forouzi, M. A., & Jahani, Y. (2016). Guided imagery effects on chemotherapy induced nausea and vomiting in Iranian breast cancer patients. Complementary Therapies in Clinical Practice, 25, 8-12. DOI:
  17. Kemenkes RI. (2015). Situasi Penyakit Kanker.
  18. Maughan, R. J., Watson, P., Cordery, P. A., Walsh, N., Oliver, S., Dolci, A., Rodríguez Sanchez, N., & Galloway, S. D. (2016). Development of a hydration index: a randomized trial to assess the potential of different beverages to affect hydration status. Am J Clin Nutr, 103(3), 717-723. DOI:
  19. Moradian, S., Walshe, C., Shahidsales, S., Reza, M., Nasiri, G., Pilling, M., & Molassiotis, A. (2014). Nevasic audio program for the prevention of chemotherapy induced nausea and vomiting : A feasibility study using a randomized controlled trial design. European Journal of Oncology Nursing, 19(3), 282-291. DOI:
  20. Muaris, H. (2014). Infused Water: Tren Gaya Hidup Minum Air Putih. Gramedia Pustaka Utama
  21. Navari, R. M. (2016). Introduction. In R. M. Navari (Ed.), Management of Chemotherapy-Induced Nausea and Vomiting New Agents and New Uses of Current Agents. Spinger. DOI:
  22. Newman, V. (2017). The Effects of Cold Drinks on Digestion. Lifestrong.Com.
  23. Noman, S., Shahar, H. K., Rahman, H. A., Ismail, S., Al-Jaberi, M. A., & Azzani, M. (2021). The effectiveness of educational interventions on breast cancer screening uptake, knowledge, and beliefs amongwomen: A systematic review. International Journal of Environmental Research and Public Health, 18(1), 1–30. DOI:
  24. Pangesti, D. N., & Sofiani, Y. (2016). Eektifitas Perbandingan Pemberian Minuman Dingin Terhadap Penurunan Sensasi Mual dan Muntah Setelah Kemoterapi pada Klien Kanker Payudara di RS Umum dr. H. Abdul Moeloek Propinsi Lampung. 7(2), 189–196. DOI:
  25. Potter, P. A., Perry, A. G., & Patricia Stockert, A. H. (2016). Fundamental Of Nursing: Potter Peery. Elsevier.
  26. Rahmatya, A., Khambri, D., & Mulyani, H. (2015). Hubungan Usia dengan Gambaran Klinikpatologi Kanker Payudara di Bagian Bedah RSUP Dr. M. Djamil Padang. Jurnal Kesehatan Andalas, 4(2), 478–484. DOI:
  27. Rapoport, B. L. (2017). Delayed Chemotherapy-Induced Nausea and Vomiting : Pathogenesis , Incidence , and Current Management. Frontiers in Pharmacology, 8, 1–10. DOI:
  28. Sari, R. I., Hartoyo, M., & Wulandari. (2015). Pengaruh Aromaterapi Peppermint terhadap Penurunan Mual Muntah Akut Pada Pasien Yang Menjalani Kemoterapi di SMC RS Telogorejo. Jurnal Ilmu Keperawatan Dan Kebidanan.
  29. Shin, E. S., Seo, K. H., Lee, S. H., Jang, J. E., Jung, Y. M., Kim, M. J., & Yeon, J. Y. (2016). Massage with or without aromatherapy for symptom relief in people with cancer. In Cochrane Library. DOI:
  30. Silbernagl, S., & Lang, F. (2016). Color Atlas of Pathophysiology. Thieme. DOI:
  31. Singh, P., Yoon, S. S., & Kuo, B. (2016). Nausea: A review of pathophysiology and therapeutics. Therapeutic Advances in Gastroenterology, 9(1), 98–112. DOI:
  32. Tsuji, D., Suzuki, K., Kawasaki, Y., Goto, K., Matsui, R., & Seki, N. (2018). Risk factors associated with chemotherapy-induced nausea and vomiting in the triplet antiemetic regimen including palonosetron or granisetron for cisplatin-based chemotherapy : analysis of a randomized , double-blind controlled trial. Supportive Care in Cancer, 27(3),1139-1147. DOI:
  33. Von Duvillard, S. P., Braun, W. A., Markofski, M., Beneke, R., & Leithäuser, R. (2004). Fluids and hydration in prolonged endurance performance. Nutrition, 20(7-8), 651-656 DOI:
  34. Widayati, D. S., Firdaus, A. D., & Handian, F. I. (2022). The Relationship Between Level of Knowledge About Early Mobilization with Pain Intensity of Post Laparotomy Patients. The Journal of Palembang Nursing Studies, 1(2), 28-33. DOI:
  35. World Health Organization (WHO). (2022). World Cancer Day: Closing the care gap. WHO.
  36. Wulandari, R. A., Maulidia, R., & Firdaus, A. D. (2022). The Relationship Between Family Support and Depression among Patient with Renal Failure Patients. The Journal of Palembang Nursing Studies, 1(2), 34-39. DOI:


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